The continuous extrusion process is being applied in many fields of life sciences and the pharmaceutical industry. In various processes - hot melt extrusion, granulation, lipid extrusion - the usage of co-rotating twin screws is well established.
With our large wealth of experience in the fields of process technology, GMP design, plant engineering, and qualification, we assist you as a competent partner: from the development stage right up to the production phase.
Apart from the use in the pharmaceutical sector for the manufacturing of, for example, granules, pellets, implants, or contraceptive vaginal rings, Leistritz technology comes also into effect in the following fields:
In most cases, hot melt extrusion is used for the dispersing of solids. The reason for this is the usage of hardly soluble active ingredients, BCS class 2 and 4, which obtain a significantly improved bioavailability through the dispersing of solids. Also, prolonged-release formulations can be produced in this way. The modular design of the twin screw extruder, together with a vast experience in the field of process engineering, is of enormous benefit. All common pharmaceutical polymers can be processed.
Leistritz twin screw extruders enable various continuous granulation processes. Due to their modular design, both hot melt granulation and wet granulation can be accomplished. Leistritz extruders can be integrated perfectly into a continuous production plant. By using suitable dies, hot melt extrusion can be accomplished as well, which is completed in a subsequent spheronization process.